Measurement and Metabolism of Nonenzymatically Glycosylated LDL
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چکیده
منابع مشابه
Nonenzymatically glycosylated serum protein: spurious elevation due to free glucose in serum.
The presence of free glucose in serum was found to interfere with accurate measurement, by a colorimetric method, of nonenzymatically glycosylated serum proteins. A mean elevation to 241% of basal levels was observed in the serum of 11 nondiabetic subjects to which glucose, in a concentration of 300 mg/dl, had been added immediately before assay. After dialysis of serum samples to remove glucos...
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Proteins of extracellular matrix undergo over time multiple reactions with glucose to form advanced glycosylation endproducts (AGEs) which are highly active in protein crosslinking, and have been implicated in tissue damage associated with aging and diabetes. A macrophage/monocyte receptor for AGE moieties mediates the uptake of AGE-modified proteins by a process that also induces cachectin/tum...
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Long term incubation of proteins with glucose, named the Maillard reaction (Maillard, L. C. (1912) C. R. Acad. Sci. (Paris) 154, 66-68), gives rise to advanced glycosylation end product (AGE) with fluorescence, color, as well as cross-linked properties. The receptor-mediated endocytosis of AGE-proteins by macrophages was reported (Vlassara, H., Brownlee, M., and Cerami, A. (1985) Proc. Natl. Ac...
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Over the past decade, there have been many reports suggesting the presence of complex carbohydrates on nuclear and cytoplasmic proteins in mammalian cells. Some of the most often cited of these reports deal with the glycosylation of the high mobility group (HMG) proteins. These are relatively abundant chromosomal proteins that are known to be associated with nucleosomes and actively transcribed...
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The discovery, biochemistry, laboratory determination, and clinical application of glycosylated haemoglobins are reviewed. Sources of error are discussed in detail. No single assay method is suitable for all purposes, and in the foreseeable future generally acceptable standards and reference ranges are unlikely to be agreed. Each laboratory must establish its own. Nevertheless, the development ...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1986
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.13.6_1357